Mission of the lab
We use stem cell models, high throughput sequencing technologies (ChIP-seq, ATAC-seq, RNA-seq, Hi-C), CRISPR-Cas9 mediated genome editing, and computational tools, to decipher the regulatory networks orchestrating astrocyte functions in mammals and to understand the interplay between chromatin topology and gene expression.
Current research activities:
Identification of the regulatory network orchestrating gene expression patterns in astrocytes,
Isolation of genetic drivers of evolutionary changes in the biology of astrocytes,
Establishment of the role of the three-dimensional structure of chromatin in gene regulation,
Development of computational tools for analysis of chromatin topology.
We are also a part of the NIH Regulome Project