Dioscuri Centre

for Chromatin Biology and Epigenomics

Dioscuri is a program initiated by the Max Planck Society,

managed jointly with the National Science Centre (Poland) and mutually funded by the Polish Ministry of Science and Higher Education and the German Federal Ministry of Education and Research

Mission of the lab

We use stem cell models, high throughput sequencing technologies (ChIP-seq, ATAC-seq, RNA-seq, Hi-C), CRISPR-Cas9 mediated genome editing, and computational tools, to decipher the regulatory networks orchestrating astrocyte functions in mammals and to understand the interplay between chromatin topology and gene expression.

Current research activities:

  • Identification of the regulatory network orchestrating gene expression patterns in astrocytes,

  • Isolation of genetic drivers of evolutionary changes in the biology of astrocytes,

  • Establishment of the role of the three-dimensional structure of chromatin in gene regulation,

  • Development of computational tools for analysis of chromatin topology.

We are also a part of the NIH Regulome Project