I graduated from the University of Lodz with a MS in biology (spec. biophysics, lab of Prof. Grzegorz Bartosz, Dept. of Molecular Biophysics) in 2006. For my Ph.D., I joined the lab of Dr. Pierre Ferrier at the CIML in Marseilles. Combining a variety of high throughput genome analysis approaches (including ChIP-seq, RNA-seq, and microarray-based assays) and computational biology tools, we discovered a chromatin signature allowing to distinguish active from poised enhancers (Pękowska A. et al., 2011, EMBO Journal). In a purely in silico study, we show for the first time, that tissue-specific genes display a unique pattern of histone modifications (Pękowska A. et al., 2010 Genome Research).
In 2011, I obtained the EIPOD fellowship (EMBL/Marie Curie actions) and joined groups of Dr. Wolfgang Huber, Dr. Lars Steinmetz, and Dr. Paul Bertone at EMBL/EBI for an interdisciplinary postdoc. My goal was to define the relationship between cellular plasticity and chromatin topology. Using stem cell models and in-situ Hi-C, we revealed that differentiation of pluripotent stem cells to neuronal lineage coincides with a genome-wide buildup of chromatin loops and strengthening of chromatin boundaries (Pękowska A. et al., Cell Systems).
In 2016, I joined the team of Dr. Rafael Casellas at NIAMS (NIH) in Bethesda, US. In a recent paper, we described architectural stripes - specialized chromatin structures frequently involving super-enhancers (Vian L.#, Pękowska A.# et al. 2018 Cell, # equal contribution). Combining CRISPR-Cas9, Hi-C and ChIP-seq, we show that stripes rely on the action of CTCF and cohesins; and that their formation requires constant energy input.
In my spare time, I enjoy astronomy, history, and hiking.
I have graduated as a MSc of Biochemistry at Jagiellonian University in Cracow. Then, I joined Pekka Lappalainen’s lab at the University of Helsinki as a PhD student. I took advantage of a wide range of cell biology, microscopy and biochemistry methods to unravel mechanisms regulating assembly and function of contractile actin-based structures in non-muscle cells.
Currently, I am interested in functional genomics of astrocytes. Taking advantage of genome editing methods accompanied by broad molecular biology and microscopy techniques, I aim to decipher the role of certain astrocyte genes in functional and evolutionary context.
In my spare time I experiment with coffee and travels.
While studying biotechnology at the University of Life Sciences in Poznan, I became fascinated by how cells function at the molecular level. Especially I was impressed by the variety of epigenetic mechanisms that are responsible for the proper functioning of the whole organism. In the meantime, I have been awarded the “Diamond Grant”, which I carried out under the supervision of prof. dr hab. Wlodziemierz Krzyzosiak at the Institute of Bioorganic Chemistry Polish Academy of Sciences (IChB PAS). During this time, I aimed to understand the mechanistic features of allele-specific silencing provided by miRNA-like siRNA, which is used as a potential therapeutic treatment for incurable polyglutamine diseases. Afterwards, I joined the laboratory of prof. dr hab. Matthias Bochtler at the International Institute of Molecular and Cell Biology (IIMCB). There I have defended my PhD thesis on the binding properties of chromatin-reading domains of KMT2/MLL proteins.
In May 2023 I joined the Dioscuri Centre of dr Aleksanda Pekowska. I would like to contribute to a better understanding of the regulation of gene expression by enhancer-promoter interactions in the context of chromatin structure and cell differentiation.
After work I sing in a choir, dance Lindy Hop, go hiking and travel.
I am Garima, and I completed my PhD at the Indian Institute of Science under the mentorship of Dr. Swananda Marathe. My research focused on how astrocytes influence depressive-like behaviour and the efficacy of antidepressant treatments. I investigated the structural plasticity of astrocytes in the murine brain in response to stress and pharmacological interventions, uncovering novel insights into brain plasticity. After my PhD, I pursued a short postdoctoral stint at the Institut Pasteur in Paris in the lab of Prof. Chiara Zurzolo. There, I studied neuron-glia interactions in Autism Spectrum Disorders, exploring the presence of tunneling nanotubes in in vitro in Shank3 mutant mice. I also contributed to projects investigating intercellular communication in the murine cerebellum. In 2025, I joined Dr. Aleksandra Pękowska’s lab, where I am currently exploring the function of interlaminar astrocytes across different non-human primate species. I am excited to collaborate with the team and to dive deeper into the diverse and complex roles astrocytes play in the primate brain.
My research centres on deciphering how chromatin architecture and transcription factors orchestrate gene regulation during development. I am particularly fascinated by the exceptional biology of human astrocytes — star-shaped glial cells whose regulatory networks have evolved in unique ways across species. To unravel these complexities, I employ a multidisciplinary strategy that integrates cell reprogramming and CRISPR-Cas9 gene editing with high-resolution microscopy to explore nuclear architecture and protein organisation, Hi-C to chart the three-dimensional folding of the genome, and a suite of sequencing technologies (ChIP-seq, RNA-seq, ATAC-seq) to capture the dynamic landscapes of gene activity. By integrating these layers with bioinformatics, my goal is to uncover the fundamental principles linking chromatin architecture to gene regulation in development.
Prior to joining Dioscuri Centre, I worked at Jubilant Biosys Ltd and then at the Indian Institute of Science (IISc) in Bengaluru for a duration of two years in the field of cancer therapeutics. I also did a nine-month stint at the National Institute of Mental Health and Neurosciences (NIMHANS), also in Bengaluru, where my work concentrated on stem cell biology.
I obtained my MPhil degree from National Centre for BioInformatics, Quaid-i-Azam University Islamabad, Pakistan. During my MPhil studies, I worked on Population Genomics Analysis of Whole Genome Sequencing (WGS) Data in Dogs. I did internship at Lahore University of Management Sciences (LUMS) Lahore, Pakistan, involved in Biomedical Informatics Research Laboratory, Department of Biology. Prior to joining Dioscuri Centre, I worked as Lecturer in Government University Faisalabad, Pakistan affiliated campus.
I recently joined the Dioscuri Centre for Chromatin Biology and Epigenomics, I am involved in computational analysis of the data generated in the lab. Currently, my major focus is on molecular mechanisms of the regulation of gene expression.
In 2020 I completed my post-graduation majoring in Biosciences from Jamia Millia Islamia. During my M.Sc studies I worked on establishing therapeutics efficacy of Saponins in cancer. Then for a short period of time I worked as a Junior Research Fellow at Institute of Bioinformatics and Biotechnology, Bengaluru where my project was to establish the epithelial to mesenchymal transitioning in colorectal cancer cell lines.
I recently joined Dr Pekowska's lab on December, 2022 as a Ph.D. Since then I have been working with Dr Aleksandra Pekowska on a project to understand the non-canonical functions of ATP and how does it effects the chromatin organization in mouse embryonic stem cells. Apart from lab, I enjoy taking pictures, experimenting with new recipes, and doing sports.
I pursued my MSc with specialization in Biotechnology and Bioinformatics from Institute of Bioinformatics and Applied Biotechnology, Bengaluru, India. As a part of my MSc thesis, I worked on establishing hypercompact CRISPR-Cas systems in mosquito cell lines to be used as tools for understanding dengue virus (DENV) propagation in mosquito cells lines.
While studying epigenetics as part of my coursework in MSc, I became fascinated by the molecular mechanisms governing chromatin biology and role of chromatin dynamics in gene regulation and disorders.
I have obtained Marie Curie Fellowship (chrom_rare consortium) to pursue my PhD under Dr. Aleksandra Pękowska. I am trying to investigate the molecular consequences of haploinsufficiency in CEBP and p300 histone acetyltransferases underpinning the Rubinstein-Taybi syndrome.
In my spare time, I like exploring new food joints, trekking, judging a place by its coffee and reading.
I obtained my bachelor’s degree from Clinical Laboratory Sciences at the Tabriz University of Medical Sciences, Iran and a Master degree in Molecular Medicine at Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkiye. During my Master's program, I focused on neuroinflammation in microglial cells and studied the relations between inflammation and autophagy in microglia.
My current research is centered around the molecular evolution and function of interlaminar astrocytes (ILAs). I am particularly interested in understanding the evolutionary progression of ILAs and their impact on neurodegenerative diseases and neuroinflammation. In addition to my scientific pursuits, I have a passion for traveling, cooking, and music.
I graduated at Faculty of Industrial Design at the Academy of Fine Arts in Warsaw.
After studying at the Faculty of Big Data Analysis at the Warsaw School of Economics, I took and graduated an intense course of UX/UI Design at Spanish IT School Ironhack.
I started working at the Dioscuri Centre for Chromatin Biology and Epigenomics in February 2023 as an administrative coordinator.