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OPUS-22: Short description of the project and your role
Interlaminar astrocytes (ILAs) are a primate-specific morphotype of astrocytes present in the upper layers of the brain cortex. The functions of ILAs are unknown but the fact that ILAs disappear altogether in high grade Alzheimer’s disease patients, points to their relevance in normal brain functions.
We aim to determine the functions and the molecular markup of ILAs in primates using a combination of molecular biology techniques (e.g.: single nucleus RNA-seq), genome engineering approaches (CRISPR-Cas9), and cutting-edge mouse chimera models.
You have
PhD candidates should hold a master’s degree in molecular biology, biotechnology, or genetics.
PostDoc candidates should hold a PhD degree in neurosciences or molecular biology/genetics.
We require excellent work organization skills, a creative approach to research problems, team collaboration skills and motivation. Experience in laboratory work is necessary.
PostDoc
We are looking for Postdoctoral Investigator!
Previous research and Your role
Previously, we have shown that differentiation of pluripotent stem cells is accompanied by a widespread gain of strength of CTCF-bound insulators (see paper). The mechanism underlying this phenomenon is unknown. Our preliminary data revealed a defined group of protein partners of CTCF that might orchestrate the overall gain of insulatory functions of CTCF in differentiation. We have obtained knockout lines for these factors. Your project will be to address the impact of these proteins on chromatin structure and activity by molecular biology approaches (ATAC-seq, Hi-C).
You have
Candidates should hold a PhD in molecular biology, biotechnology, or genetics. We require independence and excellent work organization skills, a creative approach to research problems, team collaboration skills and motivation are a must.
For more information about the position, please contact a.pekowska@nencki.edu.pl
SONATA BIS - 11: Short description of the project
ATP, the energy currency in the living world, is present in extremely high concentration in the cell. Remarkably, ATP can also act as a solvent able to disrupt protein aggregates. We have shown in the past that reduction of ATP in the cell leads to the emergence of chromatin loops connecting specific pairs of active regulatory elements including promoters and enhancers. In this interdisciplinary project, we will bridge high throughput genomics and genome editing technologies and computational tools to determine the role of ATP in regulating promoter-enhancer dialogue.
PostDoc
We are looking for Postdoctoral Investigator!
Your role
The postdoctoral investigator will take advantage of cutting-edge molecular and cell biology techniques, including ChIP-seq, RNA-seq, Hi-C, CRISPR-Cas9 and confocal microscopy to assess the impact of ATP on the interactions between cis-regulatory elements. The successful candidate will also have the opportunity to expand skills in the field of bioinformatics and quantitative biology.
You have
Candidates should hold a PhD in molecular biology or genetics. We require independence and excellent work organization skills, a creative approach to research problems, team collaboration skills and motivation. Experience in laboratory work is necessary.
For more information about the position, please contact a.pekowska@nencki.edu.pl